背景：Noggin is a secreted protein involved at multiple stages of vertebrate embryonic development including neural induction and is known to exert its effects by inhibiting the bone morphogenetic protein （BMP）-signaling pathway.
It binds several BMPs with very high （picomolar） affinities; with a marked preference for BMP2 and BMP4 over BMP7.
By binding tightly to BMPs; Noggin prevents BMPs from binding their receptors.
Noggin binds the bone morphogenetic proteins （BMP） such as BMP-4 and BMP-7; and inhibits BMP signaling by blocking the molecular interfaces of the binding epitopes for both type I and type II receptors.
Interaction of BMP and its antagonist Noggin governs various developmental and cellular processes; including embryonic dorsal-ventral axis; induction of neural tissue; formation of joints in the skeletal system and neurogenesis in the adult brain.
Noggin plays a key role in neural induction by inhibiting BMP4; along with other TGF-＆beta; signaling inhibitors such as chordin and follistatin.
Mouse knockout experiments have demonstrated that noggin also plays a crucial role in bone development; joint formation; and neural tube fusion.
仕様
サイズ：1mg
種由来：Human
発現宿主：HEK293 Cells
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_005441.1
アミノ酸配列：Met 1-Cys 232
遺伝子構造：A DNA sequence encoding the human Noggin precursor （NP_005441.1） （Met 1-Cys 232） was fused with a polyhistidine tag at the C-terminus.
別名（遺伝子名）：Noggin;SYM1;SYNS1
分子量：24.6 kDa
組成：Lyophilized from sterile PBS; pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
