84-9364-23 Recombinant Human Osteoprotegerin/TNFRSF11B Protein （His Tag）（Active） 1mg PKSH031716
[Elabscience]
特徴
背景：Osteoprotegerin or TNFRSF11B is a member of the TNF-receptor superfamily.
This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption.
This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development.
Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification.
Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
Osteoprotegerin/TNFRSF11B acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis.
This protein may inhibit the activation of osteoclasts and promotes osteoclast apoptosis in vitro.
Bone homeostasis seems to depend on the local RANKL/OPG ratio.
Osteoprotegerin/TNFRSF11B also play a role in preventing arterial calcification, act as decoy receptor for TRAIL and protect against apoptosis.
TRAIL binding blocks the inhibition of osteoclastogenesis.
仕様
サイズ：1mg
種由来：Human
発現宿主：HEK293 Cells
純度：＞97 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_002537.3
アミノ酸配列：Met 1-Leu 401
遺伝子構造：A DNA sequence encoding the human TNFRSF11B （NP_002537.3） （Met 1-Leu 401） was fused with a polyhistidine tag at the C-terminus.
別名（遺伝子名）：Tumor necrosis factor receptor superfamily member 11B; Osteoclastogenesis inhibitory factor; Osteoprotegerin; TNFRSF11B; OCIF; OPG;PDB5;TR1
分子量：45.3 kDa
組成：Lyophilized from sterile PBS, pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
メーカーマニュアルリンク：メーカーマニュアルはこちら
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