背景：Leukotriene A-4 hydrolase, also known as LTA-4 hydrolase, Leukotriene A （4） hydrolase, LTA4H and LTA4, is cytoplasm protein which belongs to thepeptidase M1 family.
LTA4H hydrolyzes an epoxide moiety of leukotriene A4 （LTA-4） to form leukotriene B4 （LTB-4）.
This enzyme also has some peptidase activity.
The leukotrienes （LTs） are a class of structurally related lipid mediators involved in the development and maintenance of inflammatory and allergic reactions.
In the biosynthesis of LTs, arachidonic acid was converted into the unstable intermediate epoxide LTA4, which may in turn be conjugated with glutathione to form the spasmogenic LTC4, or hydrolyzed into the proinflammatory lipid mediator LTB4 in a reaction catalyzed by Leukotriene A4 hydrolase （LTA4H）.
LTB4 is a classical chemoattractant of human neutrophils and triggers adherence and aggregation of leukocytes to vascular endothelium, and also modulates immune responses.
As a bifunctional zinc metalloenzyme, LTA4H also exhibits an anion-dependant arginyl aminopeptidase activity of high efficiency and specificity in addition to its epoxide hydrolase activity.
LTA4H is regarded as a therapeutic target for inflammation.
仕様
サイズ：50ug
種由来：Human
発現宿主：Baculovirus-Insect Cells
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_000886.1
アミノ酸配列：Met 1-Asp611
遺伝子構造：A DNA sequence encoding the human LTA4H （NP_000886.1） （Met1-Asp611） was expressed with a C-terminal polyhistidine tag.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
