背景：Prostasin （Prss8）, also known as channel activating protease 1 （CAP1）, is a trypsinlike serine peptidase, and plays important roles in epithelial physiology.
It is originally purified as an active, soluble enzyme from human seminal fluid and is highly expressed in prostate, lung, kidney, salivary gland and pancreas.
Prostasin is expressed as a glycosyl-phosphatidylinositol （GPI）-anchored membrane protein in prostate epithelial cells, and also exists as a secreted proteolytic enzyme possibly via tryptic cleavage of its COOH-terminal hydrophobic domain.
Prostasin is found to activate the epithelial sodium channel （ENaC） which is tightly regulated and is critical for maintaining salt and fluid balance in the lung and kidney in both normal and pathological conditions.
Accordingly, prostasin has been proposed as a target for therapeutic inhibition in cystic fibrosis.
In addition, prostasin inhibits prostate and breast cancer cell invasion in vitro, suggesting a functional role as a suppressor of tumor invasion, as well as a regulator of gene expression during inflammation.
仕様
サイズ：50ug
種由来：Human
発現宿主：HEK293 Cells
純度：＞97 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_002764.1
アミノ酸配列：Ala 30-Arg 322
遺伝子構造：A DNA sequence encoding the mature form of human Prss8 （NP_002764.1） （Ala 30-Arg 322） was fused with a signal peptide at the N-terminus and a polyhistidine-tag at the C-terminus.
別名（遺伝子名）：CAP1;PROSTASIN
分子量：32.8 kDa
組成：Lyophilized from sterile PBS, pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
