During embryonic and early postnatal development, HB-GAM is expressed in the central and peripheral nervous system and also in several non-neural tissues, notably lung, kidney, gut and bone.
While in the adult central nervous system, it is expressed in an activity-dependent manner in the hippocampus where it can suppress long term potentiation induction.
HB-GAM has a low expression in other areas of the adult brain, but it can be induced by ischemic insults, or targeted neuronal damaged in the entorhinal cortex or in the substantia nigra pars compacta.
It is structurally related to midkine and retinoic acid induced heparin-binding protein and has a high affinity for heparin.
HB-GAM binds anaplastic lymphoma kinase （ALK） which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation.
It also functions as a secreted growth factor and induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells.
仕様
サイズ：100ug
種由来：Human
発現宿主：Baculovirus-Insect Cells
純度：＞90 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_002816.1
アミノ酸配列：Met 1-Asp168
遺伝子構造：A DNA sequence encoding the mature form of human PTN （NP_002816.1） （Met1-Asp168） was expressed.
別名（遺伝子名）：HARP;HBGF8;HBNF;NEGF1
分子量：15.3 kDa
組成：Lyophilized from sterile 20mM Tris, 1M NaCl, pH 8.0
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
