背景：Leukotriene A-4 hydrolase; also known as LTA-4 hydrolase; Leukotriene A （4） hydrolase; LTA4H and LTA4; is cytoplasm protein which belongs to thepeptidase M1 family.
LTA4H hydrolyzes an epoxide moiety of leukotriene A4 （LTA-4） to form leukotriene B4 （LTB-4）.
This enzyme also has some peptidase activity.
The leukotrienes （LTs） are a class of structurally related lipid mediators involved in the development and maintenance of inflammatory and allergic reactions.
In the biosynthesis of LTs; arachidonic acid was converted into the unstable intermediate epoxide LTA4; which may in turn be conjugated with glutathione to form the spasmogenic LTC4; or hydrolyzed into the proinflammatory lipid mediator LTB4 in a reaction catalyzed by Leukotriene A4 hydrolase （LTA4H）.
LTB4 is a classical chemoattractant of human neutrophils and triggers adherence and aggregation of leukocytes to vascular endothelium; and also modulates immune responses.
As a bifunctional zinc metalloenzyme; LTA4H also exhibits an anion-dependant arginyl aminopeptidase activity of high efficiency and specificity in addition to its epoxide hydrolase activity.
LTA4H is regarded as a therapeutic target for inflammation.
仕様
サイズ：100ug
種由来：Human
発現宿主：E.coli
純度：＞97 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜0.005 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：P17931
アミノ酸配列：Met 1-Ile 250
遺伝子構造：A DNA sequence encoding the human Galectin3 （P17931） （Met 1-Ile 250） was expressed and purified.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
