背景：Programmed death ligand 2 （PD-L2）; also referred to as B7-DC and CD273; is a member of the B7 family of proteins including B7-1; B7-2; B7-H2; B7-H1 （PD-L1）; and B7-H3.
PD-L2 is a type I membrane protein and structurally consists of an extracellular region containing one V-like and one C-like Ig domain; a transmembrane region; and a short cytoplasmic domain.
PD-L2 is expressed on antigen presenting cells; placental endothelium and medullary thymic epithelial cells; and can be induced by LPS in B cells; INF-＆amp;gamma; in monocytes; or LPS plus IFN-＆amp;gamma; in dendritic cells.
The CD28 and B7 protein families are critical regulators of immune responses.
PD-L2 and PD-L1 are two ligands for PD-1; member of the CD28/CTLA4 family expressed on activated lymphoid cells; and thus provide signals for regulating T cell activation and immune tolerance.
The interaction of B7-DC/PD-1 exhibited a 2-6-fold higher affinity compared with the interaction of B7-H1/PD-1.
仕様
サイズ：1mg
種由来：Human
発現宿主：HEK293 Cells
純度：＞98 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_079515.2
アミノ酸配列：Met 1-Pro 219
遺伝子構造：A DNA sequence encoding the extracellular domain （Met 1-Pro 219） of human PD-L2 （NP_079515.2） was expressed with a C-terminal polyhistidine tag.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
