背景：Leptin Receptor or CD295 belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins.
This protein is a receptor for leptin （an adipocyte-specific hormone that regulates body weight）, and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis.
Leptin Receptor/CD295 is a transmembrane catalytic receptors found on NPY/AgRP and alpha-MSH/CART neurons in hypothalamic nuclei.
Leptin receptors （Ob-Rs） are coded for by one human gene that produces six different isoforms; Ob-Ra - Ob-Rf.
Ob-Rs exist as constitutive dimers at physiological expression levels.
Only the Ob-Rb isoform can transduce intracellular signals and does so through activation of the JAK2/STAT3, PI 3-K and MAPK signaling cascades.
Activation of Ob-Rs mediates transcriptional regulation of the hypothalamic melanocortin pathway and downregulates endocannabinoid expression.
Leptin acts via leptin receptors.
Leptin resistance has been proposed as a pathophysiological mechanism of obesity.
In obese individuals, Ob-Ra （which is involved in active transport of leptin across the blood-brain barrier） expression is downregulated and the individual may be unresponsive to leptin signals.
Ob-R antagonists are of great interest in the development of pharmacological treatments for obesity.
Mutations in Leptin Receptor/CD295 have been associated with obesity and pituitary dysfunction.
仕様
サイズ：1mg
種由来：Human
発現宿主：HEK293 Cells
純度：＞90 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_002294.2
アミノ酸配列：Met 1-Asp 839
遺伝子構造：A DNA sequence encoding the extracellular domain （Met 1-Asp 839） of human leptin receptor precursor （NP_002294.2） was expressed with the C-terminal fused polyhistidine-tagged Fc region of human IgG1.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
