背景：HGF activator （HGFA） is a serum-derived serine protease and belongs to the peptidase family S1.HGFA is responsible for the conversion of hepatocyte growth factor （HGF）, from the inactive single-chain precursor to the active heterodimeric form, which is a potent mitogen, motogen, and morphogen for liver cells, epithelial cells, and endothelial cells.
HGFA is synthesized and secreted by the liver and circulates in the plasma as an inactive single-chain zymogen in normal states.
The zymogen is cleaved by thrombin or thermolysin through the endoproteolytic process and forms an active heterodimer linked by a disulfide bond.
In turn, the active protease can be inhibited by HGFA inhibitors （HAIs） including HAI-1 and HAI-2.
In addition, the HGFA zymogen acquires a strong affinity upon activation and thus may ensure the local action in tissue regeneration in liver, kidney and skin.
It has been reported that activation of HGF is a critical limiting step in the HGF/SF-induced signaling pathway mediated by Met, and accordingly, aberrant expression of HGFA is implicated in tumorigenesis and progression.
仕様
サイズ：50ug
種由来：Human
発現宿主：HEK293 Cells
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_001519.1
アミノ酸配列：Met 1-Ser 655
遺伝子構造：A DNA sequence encoding the human HGF activator precursor （NP_001519.1） （Met 1-Ser 655） was expressed with a fused polyhistidine-tag at the C-terminus.
別名（遺伝子名）：HGFA;MGC138395;MGC138397;RP11-529E10.2
分子量：68.2 kDa
組成：Lyophilized from sterile PBS, pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
