84-9363-97　Recombinant Human CD50/ICAM-3 Protein （His Tag）（Active） 100ug　PKSH031675

特徴

• 背景：The protein ICAM-3, also known as CD50, is a member of the intercellular adhesion molecule （ICAM） family consisting three members.
• It is a DC-SIGN ligand that is constitutively expressed on resting leukocytes, and is thus an important molecule for the first immune response.
• ICAM-3 comprises of five immunoglobulin-like domains, and binds LFA-1 through its two N-terminal domains.
• It functions not only as an adhesion molecule, but also as a potent signalling molecule.
• ICAM-3 binds to LFA-1 on antigen-presenting cells （APC） stabilizing the T cell-APC interaction, facilitating signaling through the CD3/TCR complex.
• However, recent evidence using cultured and transformed T cells suggests ICAM-3 may also function in signaling.
• It has been reported that CD50 molecule can play a role in developing functionally mature T lymphocytes and its expression increases during the maturation process of T lymphocytes.
• In addition, the interactions of ICAM-3 and LFA-1 facilitate HIV-1- induced virological synapse formation between T cells.
• ICAM-3 is associated with an increase of cellular radio-resistance and cancer cell proliferation.
• It could be considered as a candidate for anti-cancer drug development and as a cancer diagnostic marker.