背景：Interleukin-13 receptor subunit alpha-2 （IL13RA2/IL-13RA2） is also known as also known as cluster of differentiation 213A2 （CD213A2）, IL-13 receptor subunit alpha-2, IL-13R subunit alpha-2, and IL-13RA2.
The IL13RA2 is often overexpressed in brain tumors, making Il13ra2 one of the vaccine targets for immunotherapy of glioma.
IL13RA2/IL-13RA2 is a cancer-associated receptor that is present in greater than 80％ of High Grade Astrocytomas （HGA） and has recently been recognized as a cytokine that predisposes breast cancer cells to metastasize.
Expression of IL13R＆alpha;2 was rapidly lost from the surface of transduced cells grown in culture.
The loss appeared to be related to ligands present in fetal bovine serum in the medium.
None of the malignant glioma cell lines cultivated in vitro and tested to date exhibited the IL13R＆alpha;2 receptor.
A recombinant virus （R5111） enters cells via its interaction with the IL13R＆alpha;2 receptor in a manner that cannot be differentiated from the interaction of wild-type virus with its receptors.
仕様
サイズ：1mg
種由来：Human
発現宿主：HEK293 Cells
純度：＞85 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_000631.1
アミノ酸配列：Met 1-Leu342
遺伝子構造：A DNA sequence encoding the extracellular domain of human IL13Rα2 （NP_000631.1） （Met1-Leu342） was expressed with the a polyhistidine tag at the C-terminus.
別名（遺伝子名）：CD213A2;CT19;IL-13R;IL13BP;IL13R
分子量：38 kDa
組成：Lyophilized from sterile PBS, pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
