背景：Programmed cell death 1; also known as PDCD1; is a type I transmembrane glycoprotein; and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase; SHP-2 upon interacting with either of two ligands; PD-L1 or PD-L2.
PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1; IL-4; IL-10 and IFN-＆gamma; by suppressing the activation and transduction of PI3K/AKT pathway.
In addition; coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer.
PD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance; and thus contributes to the prevention of autoimmune diseases.
Furthermore; PD1 is shown to be a regulator of virus-specific CD8+ T cell survival in HIV infection.
As a cell surface molecule; PDCD1 regulates the adaptive immune response.
Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation; cytokine production; and cytolytic function.
仕様
サイズ：1mg
種由来：Human
発現宿主：HEK293 Cells
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_005009.2
アミノ酸配列：Met 1-Gln 167
遺伝子構造：A DNA sequence encoding the extracellular domain （Met 1-Gln 167） of human PD1 （NP_005009.2） was expressed with a C-terminal polyhistidine tag.
別名（遺伝子名）：Programmed cell death protein 1;PDCD1;PD-1;hPD-1;CD279;SLEB2;Hsle1
分子量：17.4 kDa
組成：Lyophilized from sterile PBS; pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
