背景：Interleukin 6 receptor （IL-6R） also known as CD126 （Cluster of Differentiation 126） is a type I cytokine receptor.
The low concentration of a soluble form of IL-6 receptor （sIL-6R） acts as an agonist of IL-6 activity.
In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a sIL-6R protein are able to mediate IL-6 signals into the cells through the interaction of gp130.
The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signalling.
Through this so-called 'trans-signalling' mechanism, IL-6 is able to stimulate cells that lack an endogenous mIL-6R.
High levels of IL-6 and sIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.
仕様
サイズ：1mg
種由来：Human
発現宿主：HEK293 Cells
純度：＞90 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_000556.1
アミノ酸配列：Met 1-Pro 365
遺伝子構造：A DNA sequence encoding the extracellular domain of human IL6R （NP_000556.1） corresponding to amino acid （Met 1-Pro 365） was expressed with a C-terminal polyhistidine tag.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
