背景：Tumor necrosis factor receptor superfamily, member 1B （TNFRSF1B）, also known as Tumor necrosis factor receptor 2 （TNFR2） or CD120b antigen, is a member of the tumor necrosis factor receptor superfamily.
TNFR2/CD120b/TNFRSF1B is a member of the TNF-receptor superfamily.
This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity.
Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.
TNFR2/CD120b/TNFRSF1B is not a major contributing factor to the genetic risk of type 2 diabetes, its associated peripheral neuropathy and hypertension and related metabolic traits in North Indians.
Tumor necrosis factor receptor superfamily, member 1B （TNFRSF1B） has been reported to be associated with SLE risk in Japanese populations.
TNFR2/CD120b/TNFRSF1B serves as a receptor with high affinity for TNFSF2 and approximately 5-fold lower affinity for homotrimeric TNFSF1.
This receptor mediates most of the metabolic effects of TNF-alpha.
Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
仕様
サイズ：1mg
種由来：Human
発現宿主：HEK293 Cells
純度：＞97 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_001057.1
アミノ酸配列：Met 1-Asp 257
遺伝子構造：A DNA sequence encoding the extracellular domain （Met 1-Asp 257） of human TNFRII （NP_001057.1） was expressed, fused with a C-terminal polyhistidine tag.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
