背景：TROP-2, also referred to as tumor associated calcium signal transducer 2 （TACSTD2）, GA733-1 or M1S1, is a cell surface glycoprotein highly expressed in a wide variety of epithelial cancers.
In contrast, there is little or no expression of Trop-2 in adult somatic tissue.
Because it is a cell surface protein that is selectively expressed in tumor cells, Trop-2 is a potential therapeutic target.
The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence.
Trop-2 transduces an intracellular calcium signal, are consistent with the hypothesis that it acts as a cell surface receptor and support a search for a physiological ligand.
TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type I membrane proteins.
The other known member is GA733-2, also called EpCAM and TROP1.
It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate.
仕様
サイズ：1mg
種由来：Human
発現宿主：HEK293 Cells
純度：＞96 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_002344.2
アミノ酸配列：Met 1-Thr 274
遺伝子構造：A DNA sequence encoding the extracellular domain （Met 1-Thr 274） of human TROP2 （NP_002344.2） was expressed, fused with a polyhistidine tag at the C-terminus.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
