背景：The carbonic anhydrases （or carbonate dehydratases） are classified as metalloenzyme for its zinc ion prosthetic group and form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bicarbonate and protons, a reversible reaction that takes part in maintaining acid-base balance in blood and other tissues.
The carbonic anhydrasekl （CA） family consists of at least 11 enzymatically active members and a few inactive homologous proteins.
CAXIV is a member of CA family that showed an overall similarity of 29＆ndash;46％ to other active CA isozymes.
The highest percentage similarity was with a transmembrane CA isoform, CAXII.
The CAXIV was found high concentrations in human heart, brain, liver, and skeletal muscle but lower in the colon, small intestine, urinary bladder, and kidney.
No CAXIV mRNA was seen in the salivary gland and pancreas.
CAXIV is a likely candidate for the extracellular CA postulated to have an important role in modulating excitatory synaptic transmission in brain.
仕様
サイズ：50ug
種由来：Human
発現宿主：HEK293 Cells
純度：＞97 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_036245.1
アミノ酸配列：Met 1-Met 290
遺伝子構造：A DNA sequence encoding the extracellular domain of human CA14 （NP_036245.1） （Met 1-Met 290） was expressed with a C-terminal polyhistidine tag.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
