背景：Transforming growth factor, beta receptor I, also known as Transforming growth factor-beta receptor type I , Serine / threonine-protein kinase receptor R4, Activin receptor-like kinase 5, SKR4, ALK-5, and TGFBR1, is a single-pass type I membrane protein which belongs to the protein kinase superfamily and TGFB receptor subfamily.
TGFBR1 / ALK-5 is found in all tissues examined.
It is most abundant in placenta and least abundant in brain and heart.
TGF-beta functions as a tumor suppressor by inhibiting the cell cycle in the G1 phase.
Administration of TGF-beta is able to protect against mammary tumor development in transgenic mouse models in vivo.
Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers, with the majority of colon and gastric cancers being caused by an inactivating mutation of TGF-beta RII.
On ligand binding, TGFBR1 / ALK-5 forms a receptor complex consisting of two type I I and two type I transmembrane serine/threonine kinases.
Type II receptors phosphorylate and activate type I receptors which auto-phosphorylate, then bind and activate SMAD transcriptional regulators.
TGF-beta signaling via TGFBR1 / ALK-5 is not required in myocardial cells during mammalian cardiac development, but plays an irreplaceable cell-autonomous role regulating cellular communication, differentiation and proliferation in endocardial and epicardial cells.
Defects in TGFBR1 / ALK-5 are the cause of Loeys-Dietz syndrome type 1A （LDS1A）, Loeys-Dietz syndrome type 2A （LDS2A）, and aortic aneurysm familial thoracic type 5 （AAT5）.
仕様
サイズ：100ug
種由来：Human
発現宿主：HEK293 Cells
純度：＞85 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_004603.1
アミノ酸配列：Met 1-Glu 125
遺伝子構造：A DNA sequence encoding the human TGFBR1 （NP_004603.1） extracellular domain （Met 1-Glu 125） was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
