背景：Cathepsins are proteases found in many types of cells conserved in all animals, which have a vital role in mammalian cellular turnover such as bone resorption.
The lysosomal cysteine protease Cathepsin C （CTSC）, also known as dipeptidyl peptidase I （DPPI/DPP1）, activates a number of granule-associated serine proteases with pro-inflammatory and immune functions by removal of their inhibitory N-terminal dipeptides.
This lysosomal exo-cysteine protease belonging to the peptidase C1 family.
Active cathepsin C is found in lysosomes as a 200-kDa multimeric enzyme.
Subunits constituting this assembly all arise from the proteolytic cleavage of a single precursor giving rise to three peptides： the propeptide, the alpha- and the beta-chains.
It is a central coordinator for activation of many serine proteases in immune/inflammatory cells.
Defects in the Cathepsin C have been shown to be a cause of Papillon-Lefevre disease, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis.
Cathepsin C plays a key role in the activation of several degradative enzymes linked to tissue destruction in inflammatory diseases.
Thus, it is a therapeutic target for the treatment of a number of inflammatory and autoimmune diseases.
仕様
サイズ：50ug
種由来：Human
発現宿主：HEK293 Cells
純度：＞92 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_001805.3
アミノ酸配列：Met 1-Leu 463
遺伝子構造：A DNA sequence encoding the pro form of human cathepsin C （NP_001805.3） （Met 1-Leu 463） was expressed with a polyhistidine tag at the C-terminus.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
