84-9363-45　Recombinant Human TFPI Protein （His Tag）（Active） 500ug　PKSH031525

特徴

• 背景：Tissue factor pathway inhibitor （TFPI） is the natural inhibitor of TF coagulant and signaling activities.
• It is a Kunitz-type serine proteinase inhibitor that down-regulates tissue factor-initiated blood coagulation.
• With its Kunitz domains, TFPI exhibits significant homology with human inter-alpha-trypson inhibitor and bovin basic pancreatic trypsin inhibitor.
• TFPI is the natural inhibitor of TF coagulant and signaling activities.
• The importance of TFPI in the regulation of blood coagulation is emphasized by how its activity is modulated in human disease.
• In a factor （F） Xa-dependent feedback system, TFPI binds directly and inhibits the TF-FVII/FVIIa complex.
• Normally, TFPI exists in plasma both as a full-length molecule and as variably carboxy-terminal truncated forms.
• TFPI also circulates in complex with plasma lipoproteins.
• The levels and the dual inhibitor effect of TFPI on FXa and TF-FVII/FVIIa complex offers insight into the mechanisms of various pathological conditions triggered by TF.
• TFPI may play an important role in modulating TF-induced thrombogenesis and it may also provide a unique therapeutic approach for prophylaxis and/or treatment of various diseases.
• In addition, Studies have shown that TFPI exhibits antiangiogenic and antimetastatic effects in vitro and in vivo.
• In animal models of experimental metastasis, both circulating and tumor cell-associated TFPI are shown to significantly reduce tumor cell-induced coagulation activation and lung metastasis.