背景：NKG2D, also known as CD314, is an immune receptor which consists of two disulphide-linked type II transmembrane proteins with short intracellular proteins uncapable to transduce signals.
In order to transduce signals, NKG2D needs adaptor proteins and it uses two adaptor proteins, DAP10 and DAP12.
These two adaptor proteins associate as homodimers to NKG2D- therefore the entire receptor complex appears as a hexamer.
NKG2D can send co-stimulatory signals to activate CD8 T cells.
NKG2D also plays an important role in viral control.
Cellular stress can induce ligands for NKG2D which results in the cell susceptible to NK cell-mediated lysis.
仕様
サイズ：1mg
種由来：Human
発現宿主：Baculovirus-Insect Cells
純度：＞90 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_031386.2
アミノ酸配列：Phe78-Val216
遺伝子構造：A DNA sequence encoding the human NKG2D （Phe78-Val216） was fused with a polyhistide tag at the N-terminus.
別名（遺伝子名）：CD314; KLRK1;CD314 antigen;Killer cell lectin-like receptor subfamily K member 1; killer cell lectin-like receptor subfamily K; member 1; KLR; NK cell receptor D; NKG2-D; NKG2-D type II integral membrane protein; NKG2-D-activating NK recepto
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
