背景：CDK2 is a member of the Ser/Thr protein kinase family.
This protein kinase is highly similar to the gene products of S.
cerevisiae cdc28, and S.
pombe cdc2.
It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition.
Cdks （cyclin-dependent kinases） are heteromeric serine/threonine kinases that control progression through the cell cycle in concert with their regulatory subunits, the cyclins.
Cdks are constitutively expressed and are regulated by several kinases and phosphastases, including Wee1, CDK-activating kinase and Cdc25 phosphatase.
Although there are 12 different cdk genes, only 5 have been shown to directly drive the cell cycle （Cdk1, -2, -3, -4, and -6）.
Following extracellular mitogenic stimuli, cyclin D gene expression is upregulated.
Cdk4 forms a complex with cyclin D and phosphorylates Rb protein, leading to liberation of the transcription factor E2F.
E2F induces transcription of genes including cyclins A and E, DNA polymerase and thymidine kinase.
Cdk4-cyclin E complexes form and initiate G1/S transition.
Subsequently, Cdk1-cyclin B complexes form and induce G2/M phase transition.
Cdk1-cyclin B activation induces the breakdown of the nuclear envelope and the initiation of mitosis.
CDK2 associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 （CDKN1A） and p27Kip1 （CDKN1B）.
Its activity is also regulated by its protein phosphorylation.
CDK2 is involved in the control of the cell cycle.
It also interacts with cyclins A, B1, B3, D, or E.
Activity of CDK2 is maximal during S phase and G2.
仕様
サイズ：500ug
種由来：Human
発現宿主：Baculovirus-Insect Cells
純度：＞85 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_001789.2
アミノ酸配列：Met 1-Leu 298
遺伝子構造：A DNA sequence encoding the human cyclin-dependent kinase 2 isoform 1 （NP_001789.2） （Met 1-Leu 298） was expressed, fused with a polyhistidine tag at the C-terminus.
別名（遺伝子名）：Cyclin-Dependent Kinase 2; Cell Division Protein Kinase 2; p33 Protein Kinase; CDK2; CDKN2
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
