背景：Interleukin-2 receptor （IL-2R） also known as High affinity IL-2 receptor subunit beta, IL-2 receptor subunit beta, and IL-2RB, is involved in T cell-mediated immune responses.
CD122/IL-2RB is present in 3 forms with respect to ability to bind interleukin 2.
The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction.
The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer.
Both the intermediate and high affinity forms of CD122/IL-2RB are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2.
CD122/IL-2RB expression was restricted to the earliest B220+ cells （CD43+CD24-; prepro B cells; fraction A） that proliferate vigorously to IL-2 in the absence of any stromal cells, but not to IL-15.
The high-affinity form of this receptor is expressed on activated T lymphocytes, activated B lymphocytes, and activated macrophages.
CD122/IL-2RB plays a role in regulating normal lymphocyte development.
仕様
サイズ：100ug
種由来：Human
発現宿主：HEK293 Cells
純度：＞90 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_000869.1
アミノ酸配列：Met 1-Asp 239
遺伝子構造：The mature form of human IL2 Rβ （NP_000869.1） extracellular domain （Met 1-Asp 239） with five amino acids （DDDDK） at the C-terminus was expressed and purified.
別名（遺伝子名）：CD122;IL15RB;P70-75
分子量：25.2 kDa
組成：Lyophilized from sterile 100mM NaCl, 50mM Tris, pH 7.5
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
