背景：TEK, or TIE-2, is an endothelial cell-specific receptor tyrosine kinase （RTK） that is known as a functioning molecule of vascular endothelial cells.
TEK comprises a subfamily of RTK with TIE, and these two receptors play critical roles in vascular maturation, maintenance of integrity and remodeling.
Targeted mutagenesis of both Tek and its agonistic ligand, Angiopoietin-1, result in embryonic lethality, demonstrating that the signal transduction pathways mediated by this receptor are crucial for normal embryonic development.
TEK signaling is indispensable for the development of the embryonic vasculature and suggests that TEK signaling may also be required for the development of the tumor vasculature.
仕様
サイズ：1mg
種由来：Human
発現宿主：HEK293 Cells
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_000450.2
アミノ酸配列：Met 1-Lys 745
遺伝子構造：A DNA sequence encoding the extracellular domain （Met 1-Lys 745） of human Tie2 （NP_000450.2） precursor was fused with a polyhistidine tag at the C-terminus.
別名（遺伝子名）：CD202B;TIE-2;TIE2;VMCM;VMCM1
分子量：82 kDa
組成：Lyophilized from sterile PBS, pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
