背景：Leukocyte-derived arginine aminopeptidase （LRAP）, also known as endoplasmic reticulum-aminopeptidase 2 （ERAP2）, is the second identified aminopeptidase localized in the in the lumenal side of endoplasmic reticulum （ER） processing antigenic peptides presented to major histocompatibility complex （MHC） class I molecules.
It is a 960-amino acid protein with significant homology to placental leucine aminopeptidase and adipocyte-derived leucine aminopeptidase.
LRAP preferentially hydrolyzes the basic residues Arg and Lys, and contains the HEXXH（X）18E zinc-binding motif, which is the characteristic of the M1 family of zinc metallopeptidases which also includes PILS/ARTS1/ERAP1 and LNPEP/PLAP.
Induced by interferon-gamma, LRAP is able to trim various MHC class I antigenic peptide precursors.
仕様
サイズ：50ug
種由来：Human
発現宿主：HEK293 Cells
純度：＞98 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_071745.1
アミノ酸配列：Ala 56-Thr 960
遺伝子構造：A DNA sequence encoding the lumenal domain of human ERAP2 （NP_071745.1） （Ala 56-Thr 960） was expressed with a polyhistidine tag at the N-terminus.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
