背景:kallikrein-related peptidase 11 (KLK11); also known as hippostasin; trypsin-like serine protease and PRSS20; is a member of human tissue kallikrein family.
It is a subgroup of serine proteases with diverse physiological functions; which is implicated in carcinogenesis and some with potential that serving as novel biomarkers for ovarian and prostate cancer and other diseases.
The KLK11 gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19.
Two alternatively spliced forms exist; resulting in 250 (isoform 1) and 282 (isoform 2) amino acid sequences.
Isoform 2 is identical to isoform 1; except for an inserted 32 amino acid segment.
Isoform 1 is predominantly expressed in brain whereas isoform 2 is preferentially expressed in prostate.
仕様
サイズ:50ug
種由来:Human
発現宿主:HEK293 Cells
純度:>90 % as determined by reducing SDS-PAGE.
エンドトキシン濃度:<1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.:NP_006844.1
アミノ酸配列:Met 1-Asn 250
遺伝子構造:A DNA sequence encoding the human KLK11 isoform 1 (NP_006844.1) (Met 1-Asn 250) with a C-terminal polyhistidine tag was expressed.
保存条件:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.