背景：Platelet-activating factor acetylhydrolase; also known as 1-alkyl-2-acetylglycerophosphocholine esterase; 2-acetyl-1-alkylglycero-phosphocholine esterase; Group-VIIA phospholipase A2; LDL-associated phospholipase A2; PAF 2-acylhydrolase; PLA2G7 and PAFAH; is secreted protein which belongs to theAB hydrolase superfamily and Lipase family.
PLA2G7 / PAFAH modulates the action of platelet-activating factor （PAF） by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF.
It has a specificity for substrates with a short residue at the sn-2 position.
It is inactive against long-chain phospholipids.
PLA2G7 / PAFAH is a potent pro- and anti-inflammatory molecule that has been implicated in multiple inflammatory disease processes; including cardiovascular disease.
PLA2G7 also represents an important; potentially functional candidate in the pathophysiology of coronary artery disease （CAD）.
Defects in PLA2G7 are the cause of platelet-activating factor acetylhydrolase deficiency （PLA2G7 deficiency）.
It is a trait which is present in 27％ of Japanese.
It could have a significant physiologic effect in the presence of inflammatory bodily responses.
仕様
サイズ：50ug
種由来：Human
発現宿主：HEK293 Cells
純度：＞88 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：Q13093-1
アミノ酸配列：Met 1-Asn 441
遺伝子構造：A DNA sequence encoding the human PLA2G7 （Q13093-1） precursor （Met 1-Asn 441） was expressed; with a C-terminal polyhistidine tag.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
