背景：CLEC1B, also known as CLEC2, is a C-type lectin-like receptor expressed in myeloid cells and NK cells.
Natural killer （NK） cells express multiple calcium-dependent （C-type） lectin-like receptors, such as CD94 and NKG2D, that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion.
CLEC2 acts as a receptor for the platelet-aggregating snake venom protein rhodocytin.
Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase （Syk） and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2.
CLEC2 contains 1 C-type lectin domain and is expressed preferentially in the liver.
It acts as an attachment factor for human immunodeficiency virus type 1 （HIV-1） and facilitates its capture by platelets.
仕様
サイズ：1mg
種由来：Human
発現宿主：HEK293 Cells
純度：＞76 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_057593.3
アミノ酸配列：Gln 58-Pro 229
遺伝子構造：A DNA sequence encoding the human CLEC1B （NP_057593.3） extracellular domain （Gln 58-Pro 229） with a N-terminal polyhistidine tag was expressed.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
