背景：Transferrin receptor protein 1, also known as transferrin receptor, Trfr, p90, CD71 and TFRC, is a single-pass type II membrane protein which belongs to thepeptidase M28 family and M28B subfamily.
TFRC / CD71 is a membrane-bound protein expressed in larger amounts in proliferating.
The specific expression of TFRC can represent a diagnostic tool or a therapeutic target in solid tumours expressing this antigen.
Transferrin receptor is necessary for development of erythrocytes and the nervous system.
TFRC / CD71 is regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR.
Up-regulated upon mitogenic stimulation.
TFRC / CD71 represents a marker of malignant transformation in the pancreas that could be applied as potential diagnostic and therapeutic target.
仕様
サイズ：1mg
種由来：Human
発現宿主：HEK293 Cells
純度：＞85 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_003225.2
アミノ酸配列：Cys 89-Phe 760
遺伝子構造：A DNA sequence encoding the extracellular domain of human TFRC （NP_003225.2） （Cys 89-Phe 760） was expressed with a polyhistidine tag at the N-terminus.
別名（遺伝子名）：Transferrin receptor protein 1; TR; TfR; Trfr; T9; p90;CD71;T9;TFR;TFR;TRFR
分子量：77.4 kDa
組成：Lyophilized from sterile PBS, pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
