84-9362-85　Recombinant Human CD16b/FCGR3B Protein （His Tag） 100ug　PKSH031292

特徴

• 背景：The cluster of differentiation （CD） system is commonly used as cell markers in immunophynotyping.
• Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell.
• There are more than 320 CD unique clusters and subclusters have been identified.
• Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell.
• Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion.
• Cluster of differentiation 24, also known as signal transducer CD24 or heat stable antigen CD24 （HSA）, is a mucin-type glycosylphosphatidylinositol-linked glycoprotein expressed on the surface of B-cells, differentiating neuroblasts and many tumors.
• It is involved in molecular adhesion and metastatic tumor spread and serve as a normal receptor for P-selectin.
• The CD24 / P-selectin pathway could be important in dissimenating of tumor cells by facilitating the interaction with platelet and endothelial cells.
• It has also been considered as a tumor marker.
• High rate of CD24 expressions have been found in epithelial ovarian cancer, breast cancer, non-small cell lung cancer, prostate cancer and pancreatic cancer.