背景：The asialoglycoprotein receptor （ASGPR）, an endocytotic cell surface receptor expressed by hepatocytes, is triggered by triantennary binding to galactose residues of macromolecules such as asialoorosomucoid （ASOR）.
ASGPR belongs to the long-form subfamily of the C-type/Ca2+ dependent lectin family.
It is a complex of two noncovalently-linked and highly homologous subunits, a major 42 kDa glycoprotein ASGPR1（MHL-1） and a minor 51 kDa glycoprotein ASGR2 （MHL-2）.
ASGPR1 is synthesized as a type II transmembrane protein that contains a cytosolic N-terminal domain, a single transmembrane segment, and an extracellular domain which contains two important structural regions.
The first is a stalk domain that contributes to noncovalent oligomerization, and the second is a Ca2+-dependent carbohydrate binding domain at the very C-terminus that is unusually stabilized by three ions.
The research regarded that ASGPR1 could be targeted for anti- hepatitis B virus （HBV） drug development.
仕様
サイズ：1mg
種由来：Human
発現宿主：HEK293 Cells
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_000561.3
アミノ酸配列：Met 1-Ser 200
遺伝子構造：A DNA sequence encoding the human CD16b （NP_000561.3） （Met 1-Ser 200） was fused with a polyhistidine tag at the C-terminus.
別名（遺伝子名）：Low affinity immunoglobulin gamma Fc region receptor III-B; Fc-gamma RIII-beta; FcR-10; IgG Fc receptor III-1; FCG3; FCGR3; CD16b and FCGR6B;FCRIII;FCRIIIb
分子量：22.2 kDa
組成：Lyophilized from sterile PBS, pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
