84-9362-83　［取扱停止］Recombinant Human CD16b/FCGR3B Protein （Active） 1mg　PKSH031290

特徴

• 背景：Carbohydrate sulfotransferase 15; also known as N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase; GalNAc4S-6ST; B-cell RAG-associated gene protein; CHST15 and BRAG; is a single-pass type II membrane protein which belongs to thesulfotransferase 1 family.
• CHST15 / BRAG is expressed in B-cell-enriched tissues but not in fetal or adult thymus.
• It is expressed in fetal and adult spleen; lymph node; tonsil; bone marrow and peripheral leukocytes.
• It is not expressed in T-cells.
• In pro-B; pre-B; and mature B-cell lines; it colocalizes with RAG1.
• CHST15 / BRAG is a sulfotransferase that transfers sulfate from 3'-phosphoadenosine 5'-phosphosulfate （PAPS） to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E containing GlcA-GalNAc（4;6-SO4） repeating units.
• It also transfers sulfate to a unique non-reducing terminal sequence; GalNAc（4SO4）-GlcA（2SO4）-GalNAc（6SO4）; to yield a highly sulfated structure similar to the structure found in thrombomodulin chondroitin sulfate.
• CHST15 / BRAG may also act as a B-cell receptor involved in BCR ligation-mediated early activation that mediate regulatory signals key to B-cell development and / or regulation of B-cell-specific RAG expression.