背景：CEACAM5; also known as CEA or D66e; belongs to the large CEACAM subfamily of immunoglobulin superfamily.
CEACAM5 is expressed primarily by epithelial cells; and is synthesized as a glycoprotein with a MW of 180 kDa comprising 60％ carbohydrate.
CEACAM5 contains one Ig-like V-type domain at the N-terminus; followed by six Ig-like C2-type domain and a GPI anchor; and exists as a homodimer.
CEACAM5 and CEACAM6 are overexpressed in many cancers and are associated with adhesion and invasion.
CEACAM5 can mediate cell-cell adhesion through homotypic and heterotypic interactions.
It functions as a homotypic intercellular adhesion molecule and serves as a widely used tumor marker; since it is expressed at higher levels in tumorous tissues than in corresponding normal tissues.
CEACAM5 has also been shown to contribute to tumorigenicity by inhibiting cellular differentiation.
In addition; CEACAM5 is identified as the host receptor for the Dr family of adhesins of E.Coli; and the binding of E.coli Dr adhesins leads to dissociation of the CEACAM5 homodimer.
仕様
サイズ：1mg
種由来：Human
発現宿主：HEK293 Cells
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_004354.2
アミノ酸配列：Met 1-Ala 685
遺伝子構造：A DNA sequence encoding the mature form of human CEACAM5 （NP_004354.2） （Met 1-Ala 685） was fused with a polyhistidine tag at the C-terminus.
別名（遺伝子名）：CD66e;CEA
分子量：72.8 kDa
組成：Lyophilized from sterile PBS; pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
