84-9362-74 Recombinant Human R-Spondin 1/RSPO1 Protein （aa 1-146, His Tag）（Active） 1mg PKSH031268
[Elabscience]
特徴
- 背景：RSPO1 gene is a member of the R-spondin family.
- It encodes RSPO1 which is known as a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain.
- In mice, RSPO1 induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.
- This protein is an activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation.
- RSPO1 acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway.
- It also acts as a ligand for frizzled FZD8 and LRP6.
仕様
- サイズ：1mg
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：＞98 ％ as determined by reducing SDS-PAGE.
- エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションNo.：NP_001033722.1
- アミノ酸配列：Met 1-Ala 146
- 遺伝子構造：A DNA sequence encoding the amino acids （Met 1-Ala 146） of human RSPO1 （NP_001033722.1） was expressed, fused with a polyhistidine tag at the C-terminus.
- 別名（遺伝子名）：RSPO1; R-spondin1; RP11-566C13.1; CRISTIN3; FLJ40906; RSPO Rspo1; R-spondin; Rspondin; RP23-325M14.2; Roof plate-specific spondin-1
- 分子量：14 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
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84-9362-73
Recombinant Human R-Spondin 1/RSPO1 Protein （aa 1-146, His Tag）（Active） 100ug
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84-9362-74
Recombinant Human R-Spondin 1/RSPO1 Protein （aa 1-146, His Tag）（Active） 1mg
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