背景：Nicastrin （NCST, or NCT）, a single-pass membrane glycoprotein that harbors a large extracellular domain, is an essential component of the gamma-secretase complex.
Several lines of evidence indicate that the members of these complexes could also contribute to the control of cell death.
NCT controls cell death via phosphoinositide 3-kinase/Akt and p53-dependent pathways and that this function remains independent of the activity and molecular integrity of the gamma-secretase complexes.
Increasing evidences have shown that Nicastrin/NCSTN plays a crucial role in gamma-cleavage of the amyloid precursor protein （APP）.
The glycoprotein Nicastrin is an essential component of the gamma-secretase complex, a high molecular weight complex which also contains the presenilin proteins, Aph-1 and Pen-2.
The gamma-secretase complex is not only involved in APP processing but also in the processing of an increasing number of other type I integral membrane proteins.
As the largest subunit of the gamma-secretase complex, Nicastrin plays a crucial role in its activation.
Inhibition of NCSTN demonstrated an altered gamma-cleavage activity, suggesting its potential implication in developing Alzheimer's disease （AD）.
In addition, Nicastrin can function to maintain epithelial to mesenchymal transition during breast cancer progression.
Anti-nicastrin polyclonal and monoclonal antibodies were able to decrease notch1 and vimentin expression and reduced the invasive capacity of breast cancer cells in vitro.
仕様
サイズ：50ug
種由来：Human
発現宿主：HEK293 Cells
純度：＞93 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_056146.1
アミノ酸配列：Met 1-Glu 669
遺伝子構造：A DNA sequence encoding the human NCSTN （NP_056146.1） extracellular domain （Met 1-Glu 669） was expressed, with a polyhistidine tag at the C-terminus.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
