背景：15-hydroxyprostaglandin dehydrogenase [NAD+], also known as Prostaglandin dehydrogenase 1, HPGD, and PGDH1, is a member of the short-chain dehydrogenases/reductases （SDR） family.
Prostaglandins （PGs） play a key role in the onset of labor inmany species and regulate uterine contractility and cervicaldilatation.
Therefore, the regulation of prostaglandin outputby PG synthesizing and metabolizing enzymes in the human myometrium may determine uterine activitypatterns in human labor both at preterm and at term.
Prostaglandin dehydrogenase （PGDH） metabolizes prostaglandins （PGs） to render them inactive.
HPGD is down-regulated by cortisol, dexamethasone and betamethasone and down-regulated in colon cancer.
It is up-regulated by TGFB1.
HPGD contributes to the regulation of events that are under the control of prostaglandin levels.
HPGD catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4.
and inhibits in vivo proliferation of colon cancer cells.
Defects in HPGD are the cause of primary hypertrophic osteoathropathy autosomal recessive （PHOAR）, cranioosteoarthropathy （COA）,and isolated congenital nail clubbing.
仕様
サイズ：50ug
種由来：Human
発現宿主：E.coli
純度：＞92 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：Please contact us for more information.
アクセッションNo.：NP_000851.2
アミノ酸配列：Met 1-Gln 266
遺伝子構造：A DNA sequence encoding the human HPGD （NP_000851.2） （Met 1-Gln 266） was expressed, with a polyhistidine tag at the C-terminus.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
