背景：Carboxypeptidase M, also known as CPM, is a membrane-bound arginine/lysine carboxypeptidase which is a member of the carboxypeptidases family.
These enzymes remove C-terminal amino acids from peptides and proteins and exert roles in the physiological processes of blood coagulation/fibrinolysis, inflammation, food digestion and pro-hormone and neuropeptide processing.
Among the carboxypeptidases CPM is of particular importance because of its constitutive expression in an active form at the surface of specialized cells and tissues in the human body.
CPM in the brain appears to be membrane-bound via a phosphatidylinositol glycan anchor.
CPM is widely distributed in a variety of tissues and cells.
The amino acid sequence of CPM indicated that the C-terminal hydrophobic region might be a signal for membrane attachment via a glycosylphosphatidylinositol （GPI） anchor.
CPM is involved in peptide metabolism on both the cell surface and in extracellular fluids.
CPM functions not only as a protease but also as a binding partner in cell-surface protein-protein interactions.
仕様
サイズ：50ug
種由来：Human
発現宿主：HEK293 Cells
純度：＞98 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_938079.1
アミノ酸配列：Met 1-His 422
遺伝子構造：A DNA sequence encoding the human CPM （NP_938079.1） without the propeptide （Met 1-His 422） was expressed, fused with a polyhistidine tag at the C-terminus.
別名（遺伝子名）：Carboxypeptidase M;CPM
分子量：47.7 kDa
組成：Lyophilized from sterile PBS, pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
