背景：Regenerating islet-derived protein 3-alpha, also known as Regenerating islet-derived protein III-alpha, REG-3-alpha, REG3A, and HIP, is secreted protein which contains one C-type lectin domain.
REG3A is constitutively expressed in intestine, and is a pancreatic secretory protein that may be involved in cell proliferation or differentiation.
It is overexpressed during the acute phase of pancreatitis and in some patients with chronic pancreatitis.
REG3A and REG1A proteins are both involved in liver and pancreatic regeneration and proliferation.
REG3A is also a stress protein involved in the control of bacterial proliferation.
REG3A is down-regulated in most primary human gastric cancer cells, and might be useful in the diagnosis of gastric cancer.
Additionally, REG3A is a target of beta-catenin signaling in Huh7 hepatoma cells.
The REG1A and REG3A are downstream targets of the Wnt pathway during liver tumorigenesis.
仕様
サイズ：100ug
種由来：Human
発現宿主：HEK293 Cells
純度：＞97 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：Q06141-1
アミノ酸配列：Met 1-Asp 175
遺伝子構造：A DNA sequence encoding the human REG3A （Q06141-1） （Met 1-Asp 175） precursor was fused with a polyhistidine tag at the C-terminus.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
