84-9362-60　Recombinant Human Autotaxin/ENPP2 Protein （aa 49-863, His Tag） 50ug　PKSH031157

特徴

• 背景：ENPP2 （Ectonucleotide pyrophosphatase/phosphodiesterase family member 2）, also referred as Autotaxin, is a secreted enzyme encoded by the ENPP2 gene.
• This gene product stimulates the motility of tumor cells, has angiogenic properties, and its expression is upregulated in several kinds of carcinomas.
• The Autotaxin protein is important for generating the lipid signaling molecule lysophosphatidic acid （LPA）, which is a potent mitogen, which facilitates cell proliferation and migration, neurite retraction, platelet aggregation, smooth muscle contraction, actin stress formation and cytokine and chemokine secretion.
• ATX has been found to catalyze the formation of cyclic phosphatidic acid （cPA）, which have antitumor role by antimitogenic regulation of cell cycle, inhibition of cancer invasion and metastasis.
• LPA receptors and ATX are upregulated in numerous cancer cell types and show expression patterns that correlate with tumor cell invasiveness.
• Thus, Autotaxin has recently emerged as an attractive target for the development of anti-cancer chemotherapeutics.
• In addition, Serum ATX activity was found to be enhanced in relation to hepatic fibrosis in chronic liver disease due to hepatitis virus C infection.