84-9362-57　Recombinant Human CD180/RP105/LY64 Protein （His Tag）（Active） 50ug　PKSH031138

特徴

• 背景：The cluster of differentiation （CD） system is commonly used as cell markers in immunophynotyping.
• Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell.
• There are more than 320 CD unique clusters and subclusters have been identified.
• Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell.
• Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion.
• CD180, also known as RP105, is a B-cell surface molecule belonging to the family of pathogen receptors, Toll-like receptors （TLR）.
• CD180 has an extracellular leucine-rich repeats and a short cytoplasmic tail.
• CD180 / RP105 interact with an extracellular molecule named MD1 and then together form the cell surface receptor complex RP105 / MD1 which induces B-cell activation in humans and mice, leading to proliferation and up-regulation of a costimulatory molecule, B7.2 / CD86.
• CD180 / RP105 also has a role in LPS response because B cells lacking RP105 show hyporesponsiveness to LPS.