背景:NMNAT, also known as NMNAT1, is a member of the Nicotinamide-nucleotide adenylyltransferases.
It is widely expressed with high levels in skeletal muscle, heart, liver and kidney.
NMNAT appears to have the ability to protect against axonal degeneration following mechanical or toxic insults.
The coenzyme NAD and its derivatives are involved in hundreds of metabolic redox reactions and are utilized in protein ADP-ribosylation, histone deacetylation, and in some Ca(2+) signaling pathways.
NMNAT enzyme is vital for NAD biosynthesis, catalyzing the condensation of nicotinamide mononucleotide (NMN) or nicotinic acid mononucleotide (NaMN) with the AMP moiety of ATP to form NAD or NaAD.
仕様
サイズ:50ug
種由来:Human
発現宿主:Baculovirus-Insect Cells
純度:>85 % as determined by reducing SDS-PAGE.
エンドトキシン濃度:<1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.:Q9HAN9
アミノ酸配列:Met 1-Thr 279
遺伝子構造:A DNA sequence encoding the human NMNAT1 (Q9HAN9)( Met 1-Thr279) was expressed with a C-terminal polyhistidine tag.
保存条件:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.