背景：Arginase is the focal enzyme of the urea cycle hydrolysing L-arginine to urea and L-ornithine.
Emerging studies have identified arginase in the vasculature and have implicated this enzyme in the regulation of nitric oxide （NO） synthesis and the development of vascular disease.
Arginase also redirects the metabolism of L-arginine to L-ornithine and the formation of polyamines and L-proline, which are essential for smooth muscle cell growth and collagen synthesis.
Arginase is encoded by two recently discovered genes （Arginase I and Arginase II）.
In most mammals, Arginase 1 （ARG1） also known as Arginase, liver, which functions in the urea cycle, and is located primarily in the cytoplasm of the liver.
The second isozyme, Arginase II, has been implicated in the regulation of the arginine/ornithine concentrations in the cell.
It is located in mitochondria of several tissues in the body, with most abundance in the kidney and prostate.
It may be found at lower levels in macrophages, lactating mammary glands, and brain.
仕様
サイズ：100ug
種由来：Human
発現宿主：HEK293 Cells
純度：＞90 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：P05089-1
アミノ酸配列：Met 1-Lys 322
遺伝子構造：A DNA sequence encoding the human ARG1 isoform 1 （P05089-1） （Met 1-Lys 322） was fused with a polyhistidine tag at the C-terminus.
別名（遺伝子名）：Arginase-1; Liver-type arginase; Type I arginase; ARG1
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
