84-9362-50 Recombinant Human Neuregulin-1/NRG1-‑beta1 Protein （EGF Domain, Fc Tag）（Active） 1mg PKSH031068
[Elabscience]
特徴
- 背景：Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors.
- This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues.
- NRG1 is a trophic factor that has been implicated in neural development; neurotransmission; and synaptic plasticity.
- NRG1 has multiple isoforms that are generated by usage of different promoters and alternative splicing of a single gene.
- Neuregulin 1 （NRG1） is essential for the development and function of multiple organ systems; and its dysregulation has been linked to diseases such as cancer and schizophrenia.
- NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function.
- Schizophrenia is a complex disorder; with etiology likely due to epistasis.
仕様
- サイズ：1mg
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：＞86 ％ as determined by reducing SDS-PAGE.
- エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションNo.：Q02297-6
- アミノ酸配列：Thr 176-Lys 246
- 遺伝子構造：A DNA sequence encoding the EGF-like domain （Thr 176-Lys 246） of human NRG1 isoform beta1 （Q02297-6） was fused with the Fc region of human IgG1 at the N-terminus.
- 別名（遺伝子名）：Pro-neuregulin-1;Neuregulin-1 beta 1;NRG1-beta 1;HRG1-beta 1; EGF;NRG1; GGF; HGL; HRGA; NDF; SMDF;
- 分子量：36.7 kDa
- 組成：Lyophilized from sterile PBS; pH 7.4
- 保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
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