背景：Serine protease inhibitor Kazal-type 4; also known as Peptide PEC-60 homolog and SPINK4; is a secreted protein which contains one Kazal-like domain.
SPINK4 is a member of the SPINK protein family.
The gene family of serine protease inhibitors of the Kazal type （SPINK） are functional and positional candidate genes for celiac disease （CD）.
SPINK1 plays an important role in protecting the pancreas against excessive trypsinogen activation.
It is a potent natural inhibitor of pancreatic trypsin activity.
SPINK1 mutations are associated with the development of acute and chronic pancreatitis and have been detected in all forms of chronic pancreatitis.
SPINK2 functions as a trypsin/acrosin inhibitor and is synthesized mainly in the testis and seminal vesicle where its activity is engaged in fertility.
The SPINK2 protein contains a typical Kazal domain composed by six cysteine residues forming three disulfide bridges.
SPINK9 was identified in human skin.
Its expression was strong in palmar epidermis; but not detectable or very low in non palmoplantar skin.
仕様
サイズ：50ug
種由来：Human
発現宿主：HEK293 Cells
純度：＞97 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_055286.1
アミノ酸配列：Met 1-Cys 86
遺伝子構造：A DNA sequence encoding the human SPINK4 （NP_055286.1） （Met 1-Cys 86） was expressed; fused with a polyhistidine tag at the C-terminus.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
