背景：NTPDase 2, also known as ENTPD2, belongs to the ecto-nucleoside triphosphate diphosphohydrolase family （E-NTPDase）.
Members of E-NTPDase family are nucleotidases able to hydrolyze 5＆prime;-nucleoside tri- and/or diphosphates; the main role of these enzymes is the termination of purinergic signaling.
NTPDases are ubiquitous and were previously shown in other parasites including the trypanosomatides of genus Leishmania and in T.
brucei.
NTPase activity would act as a timer and is crucial to T.
gondii infection.
In L.
pneumophila it was demonstrated that an E-NTPDase, similar to CD39, is essential for intracellular bacterial multiplication.
NTPDase 2 is an integral membrane protein.
In the nervous system, it could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission.
Alternative splicing of NTPDase 2 gene results in multiple transcript variants.
仕様
サイズ：50ug
種由来：Human
発現宿主：Baculovirus-Insect Cells
純度：＞85 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：Q9Y5L3
アミノ酸配列：Thr 29-Asp460
遺伝子構造：A DNA sequence encoding the mature form of human ENTPD2 （Q9Y5L3） （Thr29-Asp460） was expressed, with a polyhistidine tag at the N-terminus.
別名（遺伝子名）：CD39L1;NTPDase-2;RP11-229P13.11-001
分子量：49.3 kDa
組成：Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
