背景：Kallikrein-4, also known as Enamel matrix serine proteinase 1, Kallikrein-like protein 1, KLK-L1, Serine protease 17, KLK4, PRSS17 and EMSP1, is a secreted protein which belongs to thepeptidase S1 family and Kallikrein subfamily.
Kallikrein-4 / KLK4 is a serine protease expressed during enamel maturation, and proteolytic processing of the enamel matrix by KLK4 is critical for proper enamel formation.
Kallikrein-4 / KLK4 is secreted by transition- and maturation-stage ameloblasts.
KLK4 aggressively degrades the retained organic matrix following the termination of enamel protein secretion.
Two proteases are secreted into the enamel matrix of developing teeth.
The early protease is enamelysin （MMP-20）.
The late protease is kallikrein 4 （KLK4）.
The principle functions of MMP-20 and KLK4 in dental enamel formation are to facilitate the orderly replacement of organic matrix with mineral, generating an enamel layer that is harder, less porous, and unstained by retained enamel proteins.
Defects in Kallikrein-4 / KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 （AI2A1） which is an autosomal recessive defect of enamel formation.
The disorder involves both primary and secondary dentitions.
仕様
サイズ：50ug
種由来：Human
発現宿主：HEK293 Cells
純度：＞94 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_004908.3
アミノ酸配列：Met 1-Ser 254
遺伝子構造：A DNA sequence encoding the human KLK4 （NP_004908.3） （Met 1-Ser 254） was expressed, with a polyhistidine tag at the C-terminus.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
