背景：Trypsin-3, also known as Trypsin III, brain trypsinogen, Serine protease 3 and PRSS3, is a secreted protein which belongs to thepeptidase S1 family.
Trypsin-3 / PRSS3 is expressed is in pancreas and brain.
It contains onepeptidase S1 domain.
Trypsin-3 / PRSS3 can degrade intrapancreatic trypsin inhibitors that protect against CP.
Genetic variants that cause higher mesotrypsin activity might increase the risk for chronic pancreatitis （CP）.
A sustained imbalance of pancreatic proteases and their inhibitors seems to be important for the development of CP.
The trypsin inhibitor-degrading activity qualified PRSS3 as a candidate for a novel CP susceptibility gene.
Trypsin-3 / PRSS3 has been implicated as a putative tumor suppressor gene due to its loss of expression, which is correlated with promoter hypermethylation, in esophageal squamous cell carcinoma and gastric adenocarcinoma.
仕様
サイズ：50ug
種由来：Human
発現宿主：HEK293 Cells
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：P35030-3
アミノ酸配列：Met 1-Ser 247
遺伝子構造：A DNA sequence encoding the human PRSS3 isoform c （P35030-3） （Met 1-Ser 247） was expressed, with a polyhistidine tag at the C-terminus.
別名（遺伝子名）：MTG;PRSS4;RP11-176F3.3;T9;TRY3;TRY4
分子量：26.6 kDa
組成：Lyophilized from sterile 50mM MES, 0.6M NaCl, pH 5.0
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
