背景：Aminopeptidase P （APP） is a hydrolase specific for N-terminal imido bonds; which are common to several collagen degradation products; neuropeptides; vasoactive peptides; and cytokines.
A membrane-bound and soluble form of this enzyme （XPNPEP2） have been identified as products of two separate genes.
XPNPEP2; the X-linked gene that encodes membranous aminopeptidase P （APP）; has been reported to associate with APP activity.
The membrane aminopeptidase P （XPNPEP2） is largely limited in distribution to endothelia and brush border epithelia.
APP and XPNPEP2 contain homologous blocks of sequence common to members of the ＆quot;pita bread-fold＆quot; protein family; of which Escherichia coli methionine aminopeptidase is the prototype.
The C-2399A variant in XPNPEP2 is associated with reduced APP activity and a higher incidence of AE-ACEi.
XPNPEP2 mRNA was detected in fibroblasts that carry the translocation; suggesting that this gene at least partially escapes X inactivation.
XPNPEP2 is a candidate gene for premature ovarian failure （POF）.
仕様
サイズ：50ug
種由来：Human
発現宿主：HEK293 Cells
純度：＞97 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：O43895
アミノ酸配列：Met 1-Ala 650
遺伝子構造：A DNA sequence encoding the human XPNPEP2 （O43895） （Met 1-Ala 650） without the pro peptide was expressed; with a polyhistidine tag at the C-terminus.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
