背景：B2M, also known as ＆beta;2-Microglobulin or CDABP0092, is a component of MHC class I molecules found expression in all nucleated cells （excludes red blood cells）.
The major function of MHC class I moleculesis is to display fragments of proteins from within the cell to T-cells and cells containing foreign proteins will be attacked.
B2M（＆beta;2-Microglobulin） is a low molecular weight protein.
It was demonstrated that B2M（＆beta;2-Microglobulin） was localized in the membranes of nucleated cells and was found to be associated with HL-A antigens.B2M（＆beta;2- Microglobulin） is present in free form in various body fluids and as a subunit of histocompatibility antigens on cell surfaces lateral to the＆alpha;3 chain.
Unlike＆alpha;3, ＆beta;2 has no transmembrane region.
Directly above ＆beta;2 lies the ＆alpha;1 chain, which itself is lateral to the ＆alpha;2.
In the absence of B2M（＆beta;2 microglobulin）, very limited amounts of MHC class I （classical and non-classical） molecules can be detected on the surface.
In the absence of MHC class I, CD8 T cells, a subset of T cells involved in the development of acquired immunity cannot develop.
Low levels of B2M（＆beta;2 microglobulin） can indicate non-progression of HIV.
仕様
サイズ：1mg
種由来：Human
発現宿主：HEK293 Cells
純度：＞97 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_004039.1
アミノ酸配列：Met 1-Met 119
遺伝子構造：A DNA sequence encoding the human B2M （NP_004039.1） （Met 1-Met 119） was expressed, with a polyhistidine tag at the C-terminus.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
