背景：NQO1 gene is a member of the NAD（P）H dehydrogenase （quinone） family and encodes a cytoplasmic 2-electron reductase.
NQO1 forms homodimers and reduces quinones to hydroquinones.
NQO1's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species.
Mutations in NQO1 gene have been associated with tardive dyskinesia （TD）, an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer.
Altered expression of NQO1 has been seen in many tumors and is also associated with Alzheimer's disease （AD）.
Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Recent pharmacological research suggests feasibility of genotype-directed redox chemotherapeutic intervention targeting NQO1 breast cancer, a common missense genotype encoding a functionally impaired NQO1 protein.
仕様
サイズ：50ug
種由来：Human
発現宿主：E.coli
純度：＞90 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：Please contact us for more information.
アクセッションNo.：P15559-1
アミノ酸配列：Met 1-Lys274
遺伝子構造：A DNA sequence encoding the mature form of human NQO1 （P15559-1） （Met1-Lys274） was expressed with a polyhistide tag at the N-terminus.
別名（遺伝子名）：DHQU;DIA4;DTD;NMOR1;NMORI;QR1
分子量：33 kDa
組成：Lyophilized from sterile PBS, pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
