背景：Alpha-Synuclein （alpha-Syn）, also known as NACP or SNCA, exists as at least two structural isoforms： one is helix-rich, membrane-bound form that both the N- and C-terminal regions of alpha-synuclein are tightly associated with membranes and the other is disordered, cytosolic form.
Synuclein is found predominantly in the presynaptic termini, in both free or membrane-bound forms.
SNCA is extensively localized in nucleus of neurons.
It has been shown that alpha-Synuclein was highly expressed in the mitochondria in olfactory bulb, hippocampus, striatum, and thalamus, where the cytosolic alpha-Synuclein was also rich.
Normally the unstructured soluble type of alpha-synuclein can aggregate to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson's disease, dementia with Lewy bodies and multiple system atrophy.
SNCA abnormality and mitochondrial deficiency are two major changes in the brain of patients with Parkinson's disease （PD）.
In addition, alpha-synuclein is an abundant component of Lewy bodies in sporadic Parkinson's disease and diffuse Lewy body disease.
仕様
サイズ：1mg
種由来：Human
発現宿主：E.coli
純度：＞97 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：Please contact us for more information.
アクセッションNo.：P37840-1
アミノ酸配列：Met 1-Ala 140
遺伝子構造：A DNA sequence encoding the mature form of human SNCA isoform 1 （P37840-1） （Met 1-Ala 140） was expressed and purified.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
